NFKBIB anticorps (Middle Region)

N° du produit ABIN2775761

Cet anticorps anti-NFKBIB est un anticorps Lapin Polyclonal détectant NFKBIB dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye et Porc.

Aperçu rapide pour NFKBIB anticorps (Middle Region) (ABIN2775761)

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NFKBIB anticorps

Épitope: Middle Region

Séquence: PILARLLRAH GAPEPEGEDE KSGPCSSSSD SDSGDEGDEY DDIVVHSSRS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 91%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NFKBIB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NFKBIB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 356 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NFKBIB

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Autre désignation: NFKBIB

Sujet: Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-766 BM449613.1 1-766 767-1189 BU634404.1 18-440 c 1190-1198 AI684894.1 1-9 c
Alias Symbols: IKBB, TRIP9
Protein Interaction Partner: VPS52, UBC, BAG3, TSPAN1, GIT2, RELA, REL, CSNK2A1, CDC25A, BAK1, APP, ZBTB7A, DNAJA3, IKBKB, CHUK, BRAP, IKBKG, TRE17, NFKBIA, NCOR2, PPARG, ESR2, POLR1D, POLR1E, POLR1A, POLR1C, POLR2H, NKIRAS2, POLR1B, NKIRAS1, LRPPRC, RASAL2, MTIF2, BTRC, CUL1, SKP1,
Protein Size: 356

Poids moléculaire: 38 kDa

ID gène: 4793

NCBI Accession: NM_002503, NP_002494

UniProt: Q15653

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades